Developing a Solution to Cure Corneal Blindness

Limbustem is a company developing an innovative therapy for limbal stem cell deficiency (LSCD), which can cause corneal blindness. Their product, Limbustem PRO AMEX, is an in vitro cultured limbal epithelial cellular therapy aimed at restoring vision and improving patients' quality of life. With over 15 years of research, Limbustem's therapy is designed to be more affordable than existing options, making it accessible to more patients. The product is currently preparing for market entry in Europe after successful trials in Türkiye.

Scientific Publications

Here are listed the relevant scientific publications highlighting the technologies and intellectual property currently owned by LimbuStem.

Selver OB, Barash A, Ahmed M, Wolosin JM. ABCG2-dependent dye exclusion activity and clonal potential in epithelial cells continuously growing for 1 month from limbal explants. Invest Ophthalmol Vis Sci. 2011; 52:4330-7.
https://doi.org/10.1167/iovs.10-5897

Selver OB, Durak I, Gurdal M, Baysal K, Ates H, Ozbek Z, Wang Z, Wu A, Wolosin JM. Corneal recovery in a rabbit limbal stem cell deficiency model by autologous grafts of tertiary outgrowths from cultivated limbal biopsy explants. Mol Vis. 2016; 22:138-49.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757454/

Gurdal M, Barut Selver O, Baysal K, Durak I. Comparison of culture media indicates a role for autologous serum in enhancing phenotypic preservation of rabbit limbal stem cells in explant culture. Cytotechnology. 2018;70: 687-700.
https://doi.org/10.1007/s10616-017-0171-7

Korkmaz I, Palamar M, Egrilmez S, Gurdal M, Yagci A, Barut Selver O. Evaluation of Limbal Stem Cell Transplant Success in Ocular Chemical Injury. Exp Clin Transplant. 2023; 21:684-690.
https://www.ectrx.org/detail/current/2023/21/8/0/684/0

Barut Selver O, Yagci A, Egrilmez S, Gurdal M, Palamar M, Cavusoglu T, Ates U, Veral A, Güven C, Wolosin JM. Limbal Stem Cell Deficiency and Treatment with Stem Cell Transplantation. Turk J Ophthalmol. 2017; 47:285-291.
https://oftalmoloji.org/articles/doi/tjo.72593

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